Reversing enzyme specificity
نویسندگان
چکیده
منابع مشابه
Substrate specificity of the gastrin-amidating enzyme.
As is the case with many other peptide hormones of the brain and gut, gastrin requires a carboxyl-terminal amide moiety for optimal biological activity. In the structure of progastrin, the carboxyl-terminal Phe of gastrin is followed by the sequence Gly93-Arg94-Arg95, which must be processed sequentially by an endoprotease, a carboxypeptidase, and an amidating enzyme to produce amidated bioacti...
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The Cyclic Redundancy Check (CRC) was developed as a checksum algorithm for the detection of data corruption in the process of data transmission or storage. However, in some scenarios there's a CRC given which a set of data is expected to have, so the data itself has to be modi ed (at the end or at some chosen position) in a way that it computes to the given CRC checksum afterwards. We present ...
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The immobilization of laccase (Aspergillus sp.) on chitosan by cross-linking and its application in bioconversion of phenolic compounds in batch reactors were studied. Investigation was performed using laccase immobilized via chemical cross-linking due to the higher enzymatic operational stability of this method as compared to immobilization via physical adsorption. To assess the influence of d...
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ژورنال
عنوان ژورنال: Nature
سال: 1989
ISSN: 0028-0836,1476-4687
DOI: 10.1038/339580a0